Paclitaxel-containing nano-engineered polymeric capsules towards cancer therapy.
Identifieur interne : 001055 ( Main/Exploration ); précédent : 001054; suivant : 001056Paclitaxel-containing nano-engineered polymeric capsules towards cancer therapy.
Auteurs : Laura Pastorino [Italie] ; Svetlana Erokhina ; Federico Caneva-Soumetz ; Carmelina RuggieroSource :
- Journal of nanoscience and nanotechnology [ 1533-4880 ] ; 2009.
English descriptors
- KwdEn :
- Breast Neoplasms (physiopathology), Capsules, Cell Line, Tumor, Cell Survival (drug effects), Crystallization (methods), Drug Carriers (chemistry), Humans, Macromolecular Substances (chemistry), Materials Testing, Molecular Conformation, Nanostructures (chemistry), Nanostructures (ultrastructure), Nanotechnology (methods), Paclitaxel (administration & dosage), Paclitaxel (chemistry), Particle Size, Polymers (chemistry), Surface Properties.
- MESH :
- chemical , administration & dosage : Paclitaxel.
- chemical , chemistry : Drug Carriers, Macromolecular Substances, Paclitaxel, Polymers.
- chemical : Capsules.
- chemistry : Nanostructures.
- drug effects : Cell Survival.
- methods : Crystallization, Nanotechnology.
- physiopathology : Breast Neoplasms.
- ultrastructure : Nanostructures.
- Cell Line, Tumor, Humans, Materials Testing, Molecular Conformation, Particle Size, Surface Properties.
Abstract
Paclitaxel is one of the anticancer agents most often used in clinical oncology practice for the treatment of ovarian, breast and non-small cell lung cancers. Nanoengineered polymeric capsules (NPCs) represent a new and very effective tool for the encapsulation and smart release of different compounds. In present work capsules were fabricated by means of the layer-by-layer assembly of oppositely charged polyelectrolytes onto colloidal particles, followed by removal of the cores at low pH to obtain hollow microcapsules. Paclitaxel was loaded into the capsule. As tumors exhibit a lower extracellular pH than normal tissues, the property of NPCs to open the pores in their shell at slightly acidic pH values could be used for the triggered release of paclitaxel within a tumor microenvironment. For the characterization of NPCs, quartz crystal microbalance was used to monitor the process of shell growth on planar supports. The effective encapsulation of paclitaxel was then demonstrated by atomic force microscopy and micro-Raman spectroscopy, whereas its release was characterized by Uv-vis spectroscopy. Finally the biological activity of encapsulated paclitaxel against human breast cancer cells was assessed.
PubMed: 19908595
Affiliations:
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Le document en format XML
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first="Federico" last="Caneva-Soumetz">Federico Caneva-Soumetz</name></author><author><name sortKey="Ruggiero, Carmelina" sort="Ruggiero, Carmelina" uniqKey="Ruggiero C" first="Carmelina" last="Ruggiero">Carmelina Ruggiero</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19908595</idno><idno type="pmid">19908595</idno><idno type="wicri:Area/PubMed/Corpus">000373</idno><idno type="wicri:Area/PubMed/Curation">000373</idno><idno type="wicri:Area/PubMed/Checkpoint">000379</idno><idno type="wicri:Area/Ncbi/Merge">000648</idno><idno type="wicri:Area/Ncbi/Curation">000648</idno><idno type="wicri:Area/Ncbi/Checkpoint">000648</idno><idno type="wicri:doubleKey">1533-4880:2009:Pastorino L:paclitaxel:containing:nano</idno><idno type="wicri:Area/Main/Merge">001065</idno><idno type="wicri:Area/Main/Curation">001055</idno><idno type="wicri:Area/Main/Exploration">001055</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Paclitaxel-containing nano-engineered polymeric capsules towards cancer therapy.</title><author><name sortKey="Pastorino, Laura" sort="Pastorino, Laura" uniqKey="Pastorino L" first="Laura" last="Pastorino">Laura Pastorino</name><affiliation wicri:level="1"><nlm:affiliation>Department of Communication, Computer and System Sciences, University of Genova, Via Opera Pia 13, 16145 Genova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Communication, Computer and System Sciences, University of Genova, Via Opera Pia 13, 16145 Genova</wicri:regionArea><wicri:noRegion>16145 Genova</wicri:noRegion></affiliation></author><author><name sortKey="Erokhina, Svetlana" sort="Erokhina, Svetlana" uniqKey="Erokhina S" first="Svetlana" last="Erokhina">Svetlana Erokhina</name></author><author><name sortKey="Caneva Soumetz, Federico" sort="Caneva Soumetz, Federico" uniqKey="Caneva Soumetz F" first="Federico" last="Caneva-Soumetz">Federico Caneva-Soumetz</name></author><author><name sortKey="Ruggiero, Carmelina" sort="Ruggiero, Carmelina" uniqKey="Ruggiero C" first="Carmelina" last="Ruggiero">Carmelina Ruggiero</name></author></analytic><series><title level="j">Journal of nanoscience and nanotechnology</title><idno type="ISSN">1533-4880</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Breast Neoplasms (physiopathology)</term><term>Capsules</term><term>Cell Line, Tumor</term><term>Cell Survival (drug effects)</term><term>Crystallization (methods)</term><term>Drug Carriers (chemistry)</term><term>Humans</term><term>Macromolecular Substances (chemistry)</term><term>Materials Testing</term><term>Molecular Conformation</term><term>Nanostructures (chemistry)</term><term>Nanostructures (ultrastructure)</term><term>Nanotechnology (methods)</term><term>Paclitaxel (administration & dosage)</term><term>Paclitaxel (chemistry)</term><term>Particle Size</term><term>Polymers (chemistry)</term><term>Surface Properties</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Paclitaxel</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Drug Carriers</term><term>Macromolecular Substances</term><term>Paclitaxel</term><term>Polymers</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Capsules</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanostructures</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Survival</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Crystallization</term><term>Nanotechnology</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Nanostructures</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term><term>Humans</term><term>Materials Testing</term><term>Molecular Conformation</term><term>Particle Size</term><term>Surface Properties</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Paclitaxel is one of the anticancer agents most often used in clinical oncology practice for the treatment of ovarian, breast and non-small cell lung cancers. Nanoengineered polymeric capsules (NPCs) represent a new and very effective tool for the encapsulation and smart release of different compounds. In present work capsules were fabricated by means of the layer-by-layer assembly of oppositely charged polyelectrolytes onto colloidal particles, followed by removal of the cores at low pH to obtain hollow microcapsules. Paclitaxel was loaded into the capsule. As tumors exhibit a lower extracellular pH than normal tissues, the property of NPCs to open the pores in their shell at slightly acidic pH values could be used for the triggered release of paclitaxel within a tumor microenvironment. For the characterization of NPCs, quartz crystal microbalance was used to monitor the process of shell growth on planar supports. The effective encapsulation of paclitaxel was then demonstrated by atomic force microscopy and micro-Raman spectroscopy, whereas its release was characterized by Uv-vis spectroscopy. Finally the biological activity of encapsulated paclitaxel against human breast cancer cells was assessed.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Caneva Soumetz, Federico" sort="Caneva Soumetz, Federico" uniqKey="Caneva Soumetz F" first="Federico" last="Caneva-Soumetz">Federico Caneva-Soumetz</name><name sortKey="Erokhina, Svetlana" sort="Erokhina, Svetlana" uniqKey="Erokhina S" first="Svetlana" last="Erokhina">Svetlana Erokhina</name><name sortKey="Ruggiero, Carmelina" sort="Ruggiero, Carmelina" uniqKey="Ruggiero C" first="Carmelina" last="Ruggiero">Carmelina Ruggiero</name></noCountry><country name="Italie"><noRegion><name sortKey="Pastorino, Laura" sort="Pastorino, Laura" uniqKey="Pastorino L" first="Laura" last="Pastorino">Laura Pastorino</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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